This 17-gene module includes GATA4, COL4A1, COL4A2, JAZF1, and PDE10A, with enrichment in extracellular matrix and collagen organization. Knockdown of ARID1A, SMAD3, FOXH1, MIXL1, and SOX17 activates this module. Knockdown of SOX4, SOX11, DR1, and SMAD5 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.