Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for INO80D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = INO80D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of INO80D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:205,885,461–205,885,910 | 200.5 kb | Distal (>10kb) Multiome | 447 | |
| chr2:206,032,139–206,032,814 | 53.9 kb | Distal (>10kb) Multiome | 47 | |
| chr2:206,079,507–206,080,446 | 6.4 kb | Proximal (<10kb) Multiome | 153 | |
| chr2:206,082,237–206,082,708 | 3.9 kb | Proximal (<10kb) Multiome | 71 | |
| chr2:206,083,576–206,086,328 | 275 bp | At TSS Multiome | 990 | |
| chr2:206,158,932–206,160,379 | 73.3 kb | Distal (>10kb) Multiome | 968 | |
| chr2:206,212,416–206,212,901 | 126.3 kb | Distal (>10kb) Multiome | 120 | |
| chr2:206,274,456–206,275,776 | 188.5 kb | Distal (>10kb) Multiome | 641 |
Genomic view of the INO80D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.