Acts upstream of or within negative regulation of apoptotic process. Located in mitochondrion and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HIGD1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIGD1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIGD1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:42,539,796–42,540,344 | 264.4 kb | Distal (>10kb) Multiome | 180 | |
| chr3:42,581,475–42,582,842 | 222.4 kb | Distal (>10kb) Multiome | 889 | |
| chr3:42,590,205–42,591,365 | 213.7 kb | Distal (>10kb) Multiome | 646 | |
| chr3:42,600,083–42,601,438 | 203.8 kb | Distal (>10kb) Multiome | 914 | |
| chr3:42,653,440–42,655,446 | 149.8 kb | Distal (>10kb) Multiome | 631 | |
| chr3:42,772,623–42,773,428 | 31.2 kb | Distal (>10kb) Multiome | 446 | |
| chr3:42,803,822–42,804,944 | 93 bp | At TSS Multiome | 881 | |
| chr3:42,805,298–42,806,226 | 1.5 kb | Proximal (<10kb) Multiome | 381 | |
| chr3:42,880,478–42,881,506 | 76.7 kb | Distal (>10kb) Multiome | 685 | |
| chr3:42,884,409–42,884,926 | 80.1 kb | Distal (>10kb) Multiome | 59 | |
| chr3:42,979,048–42,979,795 | 175.0 kb | Distal (>10kb) Multiome | 351 |
Genomic view of the HIGD1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.