Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GOT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:99,232,004–99,233,058 | 197.9 kb | Distal (>10kb) Multiome | 155 | |
| chr10:99,236,018–99,237,092 | 194.4 kb | Distal (>10kb) Multiome | 141 | |
| chr10:99,266,221–99,266,995 | 164.0 kb | Distal (>10kb) Multiome | 113 | |
| chr10:99,357,908–99,359,626 | 71.5 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,370,159–99,370,697 | 60.2 kb | Distal (>10kb) Multiome | 14 | |
| chr10:99,430,207–99,431,536 | 184 bp | At TSS Multiome | 882 | |
| chr10:99,519,844–99,520,769 | 89.6 kb | Distal (>10kb) Multiome HiCAR | 331 | |
| chr10:99,522,567–99,524,013 | 92.7 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr10:99,527,131–99,527,911 | 96.9 kb | Distal (>10kb) Multiome | 89 | |
| chr10:99,532,575–99,533,287 | 102.3 kb | Distal (>10kb) Multiome | 160 | |
| chr10:99,534,863–99,536,063 | 104.8 kb | Distal (>10kb) Multiome | 193 | |
| chr10:99,536,574–99,538,002 | 106.4 kb | Distal (>10kb) Multiome | 279 | |
| chr10:99,619,825–99,621,725 | 190.1 kb | Distal (>10kb) Multiome | 1070 | |
| chr10:99,658,847–99,660,052 | 228.8 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the GOT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.