This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for GANAB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GANAB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GANAB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:62,382,190–62,383,008 | 264.0 kb | Distal (>10kb) Multiome | 36 | |
| chr11:62,460,403–62,461,004 | 185.9 kb | Distal (>10kb) Multiome | 20 | |
| chr11:62,508,289–62,508,878 | 138.1 kb | Distal (>10kb) Multiome | 499 | |
| chr11:62,542,658–62,543,488 | 103.6 kb | Distal (>10kb) Multiome | 537 | |
| chr11:62,545,051–62,547,562 | 99.6 kb | Distal (>10kb) Multiome | 889 | |
| chr11:62,553,213–62,553,741 | 93.2 kb | Distal (>10kb) Multiome | 489 | |
| chr11:62,555,905–62,556,742 | 90.3 kb | Distal (>10kb) Multiome | 545 | |
| chr11:62,560,588–62,561,104 | 85.9 kb | Distal (>10kb) Multiome | 541 | |
| chr11:62,561,760–62,562,358 | 84.6 kb | Distal (>10kb) Multiome | 43 | |
| chr11:62,573,347–62,574,645 | 72.6 kb | Distal (>10kb) Multiome | 845 | |
| chr11:62,591,246–62,592,462 | 54.9 kb | Distal (>10kb) Multiome | 976 | |
| chr11:62,600,988–62,603,291 | 44.7 kb | Distal (>10kb) Multiome | 872 | |
| chr11:62,611,665–62,613,544 | 33.7 kb | Distal (>10kb) Multiome | 737 | |
| chr11:62,621,550–62,622,445 | 24.6 kb | Distal (>10kb) Multiome | 964 | |
| chr11:62,646,025–62,647,031 | 48 bp | At TSS Multiome | 815 | |
| chr11:62,652,836–62,653,744 | 6.7 kb | Proximal (<10kb) Multiome | 921 | |
| chr11:62,664,567–62,666,291 | 18.6 kb | Distal (>10kb) Multiome | 1020 | |
| chr11:62,671,328–62,672,522 | 25.1 kb | Distal (>10kb) Multiome | 882 | |
| chr11:62,705,543–62,707,930 | 59.7 kb | Distal (>10kb) Multiome | 760 | |
| chr11:62,708,691–62,710,293 | 63.0 kb | Distal (>10kb) Multiome | 531 | |
| chr11:62,726,557–62,728,947 | 81.0 kb | Distal (>10kb) Multiome | 1088 | |
| chr11:62,753,347–62,754,665 | 107.5 kb | Distal (>10kb) Multiome | 696 | |
| chr11:62,761,085–62,762,045 | 114.9 kb | Distal (>10kb) Multiome | 649 | |
| chr11:62,770,753–62,772,068 | 124.8 kb | Distal (>10kb) Multiome | 885 | |
| chr11:62,786,365–62,787,860 | 139.9 kb | Distal (>10kb) Multiome | 1073 | |
| chr11:62,791,569–62,792,385 | 145.4 kb | Distal (>10kb) Multiome | 805 | |
| chr11:62,804,451–62,807,080 | 158.9 kb | Distal (>10kb) Multiome | 994 | |
| chr11:62,831,037–62,832,904 | 185.4 kb | Distal (>10kb) Multiome | 870 | |
| chr11:62,839,042–62,842,743 | 194.8 kb | Distal (>10kb) Multiome | 1403 | |
| chr11:62,851,028–62,851,955 | 204.9 kb | Distal (>10kb) Multiome | 421 | |
| chr11:62,855,209–62,856,560 | 209.4 kb | Distal (>10kb) Multiome | 1071 | |
| chr11:62,862,252–62,862,948 | 216.1 kb | Distal (>10kb) Multiome | 360 | |
| chr11:62,880,343–62,881,977 | 234.3 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:62,909,033–62,909,985 | 262.8 kb | Distal (>10kb) Multiome | 366 |
Genomic view of the GANAB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.