Enables Tat protein binding activity; phospholipid binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Located in several cellular components, including autophagosome; ciliary basal body; and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GABARAPL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABARAPL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABARAPL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:10,153,098–10,154,282 | 59.2 kb | Distal (>10kb) Multiome | 400 | |
| chr12:10,205,393–10,205,841 | 7.0 kb | Proximal (<10kb) | 73 | |
| chr12:10,205,952–10,206,132 | 6.7 kb | Proximal (<10kb) | 12 | |
| chr12:10,206,929–10,207,134 | 5.7 kb | Proximal (<10kb) | 9 | |
| chr12:10,211,987–10,214,332 | 252 bp | At TSS Multiome | 873 | |
| chr12:10,215,193–10,215,806 | 2.3 kb | Proximal (<10kb) | 115 | |
| chr12:10,220,477–10,220,851 | 7.6 kb | Proximal (<10kb) | 103 | |
| chr12:10,363,919–10,365,484 | 152.3 kb | Distal (>10kb) Multiome | 514 | |
| chr12:10,673,596–10,674,631 | 461.4 kb | Distal (>10kb) Multiome HiCAR | 554 | |
| chr12:11,170,912–11,171,826 | 958.6 kb | Distal (>10kb) Multiome HiCAR | 861 | |
| chr12:11,500,146–11,501,129 | 1287.9 kb | Distal (>10kb) Multiome HiCAR | 874 |
Genomic view of the GABARAPL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.