FTL
ferritin light chain | FTL1, MGC71996, NBIA3

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Member of: DE-7 DE-7.1
Biological processes 26 terms
autolysosome (GO:0044754)autolysosome (GO:0044754)autolysosome (GO:0044754)autophagosome (GO:0005776)autophagy (GO:0006914)azurophil granule lumen (GO:0035578)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)erythrocyte differentiation (GO:0030218)extracellular exosome (GO:0070062)extracellular region (GO:0005576)ferric iron binding (GO:0008199)ferric iron binding (GO:0008199)ferritin complex (GO:0070288)ferritin complex (GO:0070288)ferrous iron binding (GO:0008198)identical protein binding (GO:0042802)intracellular iron ion homeostasis (GO:0006879)intracellular iron ion homeostasis (GO:0006879)intracellular iron ion homeostasis (GO:0006879)iron ion binding (GO:0005506)iron ion binding (GO:0005506)iron ion transport (GO:0006826)membrane (GO:0016020)protein binding (GO:0005515)
Expression (TPM)
FTL — as a Regulated Gene

TFs regulating FTL 0 TFs

Transcription factors with Perturb-seq knockdown data for FTL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FTL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to FTL

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FTL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:48,675,421–48,675,873 289.7 kb Distal (>10kb) Multiome 415
chr19:48,695,830–48,697,033 269.2 kb Distal (>10kb) Multiome 253
chr19:48,713,646–48,714,846 251.0 kb Distal (>10kb) Multiome 719
chr19:48,716,551–48,717,038 248.4 kb Distal (>10kb) Multiome 241
chr19:48,720,420–48,721,301 244.4 kb Distal (>10kb) Multiome 689
chr19:48,735,001–48,735,602 230.1 kb Distal (>10kb) Multiome 161
chr19:48,738,441–48,739,812 226.4 kb Distal (>10kb) Multiome 743
chr19:48,741,194–48,741,939 223.7 kb Distal (>10kb) Multiome 350
chr19:48,746,830–48,747,395 218.2 kb Distal (>10kb) Multiome 402
chr19:48,752,314–48,753,547 212.4 kb Distal (>10kb) Multiome 545
chr19:48,795,165–48,795,736 169.8 kb Distal (>10kb) Multiome HiCAR 724
chr19:48,806,734–48,807,478 158.4 kb Distal (>10kb) Multiome 452
chr19:48,810,774–48,811,494 154.3 kb Distal (>10kb) Multiome 662
chr19:48,812,048–48,813,099 152.8 kb Distal (>10kb) Multiome 603
chr19:48,829,998–48,830,690 135.0 kb Distal (>10kb) Multiome 55
chr19:48,835,571–48,838,073 129.5 kb Distal (>10kb) Multiome 621
chr19:48,872,000–48,873,835 92.9 kb Distal (>10kb) Multiome 987
chr19:48,895,958–48,896,628 69.0 kb Distal (>10kb) Multiome 207
chr19:48,899,782–48,900,620 65.1 kb Distal (>10kb) Multiome 710
chr19:48,933,397–48,933,948 31.7 kb Distal (>10kb) Multiome 458
chr19:48,954,440–48,955,356 10.5 kb Distal (>10kb) Multiome 905
chr19:48,963,322–48,964,187 1.5 kb Proximal (<10kb) Multiome 866
chr19:48,964,515–48,966,446 51 bp At TSS Multiome 1015
chr19:48,970,959–48,971,208 5.7 kb Proximal (<10kb) 330
chr19:48,992,571–48,994,129 28.2 kb Distal (>10kb) Multiome 852
chr19:49,017,642–49,018,292 52.6 kb Distal (>10kb) Multiome 480
chr19:49,019,277–49,019,889 54.3 kb Distal (>10kb) Multiome 233
chr19:49,055,975–49,056,714 90.9 kb Distal (>10kb) Multiome 431
chr19:49,064,668–49,065,682 99.8 kb Distal (>10kb) Multiome 226
chr19:49,071,761–49,072,903 106.7 kb Distal (>10kb) Multiome 278
chr19:49,084,646–49,086,115 120.0 kb Distal (>10kb) Multiome 1030
chr19:49,113,727–49,115,240 149.7 kb Distal (>10kb) Multiome 746
chr19:49,118,477–49,120,300 153.8 kb Distal (>10kb) Multiome 949
chr19:49,127,647–49,128,949 162.9 kb Distal (>10kb) Multiome 1000
chr19:49,129,106–49,129,678 164.3 kb Distal (>10kb) Multiome 197
chr19:49,132,975–49,134,197 168.2 kb Distal (>10kb) Multiome 179
chr19:49,142,781–49,143,252 177.8 kb Distal (>10kb) Multiome 299
chr19:49,145,727–49,146,720 180.9 kb Distal (>10kb) Multiome 511
chr19:49,148,659–49,150,947 185.3 kb Distal (>10kb) Multiome 917
chr19:49,151,539–49,152,548 186.7 kb Distal (>10kb) Multiome 497
chr19:49,157,555–49,158,336 192.5 kb Distal (>10kb) Multiome 599
chr19:49,210,032–49,211,225 245.3 kb Distal (>10kb) Multiome 366

Genome Browser

Genomic view of the FTL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:48,665,421 – 49,221,225
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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