The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for FGF13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FGF13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FGF13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:138,269,675–138,270,410 | 441.7 kb | Distal (>10kb) Multiome HiCAR | 34 | |
| chrX:138,710,307–138,710,745 | 971 bp | At TSS | 60 | |
| chrX:138,710,875–138,711,289 | 427 bp | At TSS | 84 | |
| chrX:138,711,385–138,712,390 | 161 bp | At TSS Multiome | 253 | |
| chrX:139,194,606–139,195,039 | 10.0 kb | Proximal (<10kb) | 225 | |
| chrX:139,202,708–139,204,646 | 376 bp | At TSS | 239 | |
| chrX:139,204,746–139,205,746 | 493.5 kb | Distal (>10kb) Multiome | 326 | |
| chrX:139,206,148–139,206,592 | 1.1 kb | Proximal (<10kb) | 50 | |
| chrX:139,211,514–139,211,955 | 6.5 kb | Proximal (<10kb) | 81 |
Genomic view of the FGF13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.