This module contains 11 genes including FOXP1, COL4A5, ADGRV1, FGF13, and COL4A6, with top enriched terms related to extracellular matrix organization, cell adhesion, and basement membrane components. Knockdown of SOX17 activates this module, while knockdown of EOMES and GATA4 repress it. These results suggest that endoderm-specific transcription factors normally suppress extracellular matrix gene expression during definitive endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.