Transcription factors with Perturb-seq knockdown data for ENSG00000289469. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289469 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289469, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,993,367–128,994,455 | 190.0 kb | Distal (>10kb) Multiome | 344 | |
| chr3:129,027,026–129,027,525 | 156.8 kb | Distal (>10kb) Multiome | 589 | |
| chr3:129,045,697–129,046,752 | 137.5 kb | Distal (>10kb) Multiome | 170 | |
| chr3:129,120,244–129,122,947 | 62.0 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,160,815–129,162,244 | 22.7 kb | Distal (>10kb) Multiome | 917 | |
| chr3:129,181,904–129,182,096 | 2.0 kb | Proximal (<10kb) | 62 | |
| chr3:129,183,284–129,184,525 | 114 bp | At TSS Multiome | 966 | |
| chr3:129,249,227–129,250,064 | 65.5 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,278,315–129,279,976 | 94.8 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,305,525–129,306,095 | 121.8 kb | Distal (>10kb) Multiome | 342 | |
| chr3:129,314,154–129,316,995 | 130.9 kb | Distal (>10kb) Multiome | 949 | |
| chr3:129,343,720–129,344,497 | 160.0 kb | Distal (>10kb) Multiome | 346 | |
| chr3:129,344,512–129,344,822 | 160.6 kb | Distal (>10kb) Multiome | 58 | |
| chr3:129,359,825–129,360,642 | 176.4 kb | Distal (>10kb) Multiome | 65 | |
| chr3:129,399,193–129,399,868 | 215.5 kb | Distal (>10kb) Multiome | 625 | |
| chr3:129,428,173–129,429,050 | 244.6 kb | Distal (>10kb) Multiome | 504 | |
| chr3:129,439,426–129,440,695 | 256.1 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the ENSG00000289469 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.