Transcription factors with Perturb-seq knockdown data for ENSG00000287076. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287076 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287076, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:90,710,405–90,711,308 | 8.3 kb | Proximal (<10kb) | 209 | |
| chr1:90,712,296–90,712,778 | 6.8 kb | Proximal (<10kb) | 43 | |
| chr1:90,712,970–90,713,461 | 6.2 kb | Proximal (<10kb) | 24 | |
| chr1:90,713,707–90,714,753 | 4.9 kb | Proximal (<10kb) | 45 | |
| chr1:90,716,376–90,717,130 | 2.5 kb | Proximal (<10kb) | 118 | |
| chr1:90,717,468–90,719,506 | 106 bp | At TSS | 387 | |
| chr1:90,719,598–90,720,218 | at TSS | At TSS | 103 | |
| chr1:90,721,506–90,721,744 | 1.9 kb | Proximal (<10kb) | 268 | |
| chr1:90,723,557–90,724,199 | 3.9 kb | Proximal (<10kb) | 186 | |
| chr1:90,724,825–90,726,397 | 5.2 kb | Proximal (<10kb) | 186 | |
| chr1:90,726,697–90,727,512 | 7.1 kb | Proximal (<10kb) | 71 | |
| chr1:90,728,650–90,728,880 | 9.0 kb | Proximal (<10kb) | 32 | |
| chr1:90,729,370–90,729,963 | 9.8 kb | Proximal (<10kb) | 164 |
Genomic view of the ENSG00000287076 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.