Transcription factors with Perturb-seq knockdown data for ENSG00000274310. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000274310 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000274310, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:54,457,494–54,460,098 | 7.1 kb | Proximal (<10kb) | 361 | |
| chr8:54,460,471–54,462,305 | 4.9 kb | Proximal (<10kb) | 40 | |
| chr8:54,462,393–54,463,174 | 4.0 kb | Proximal (<10kb) | 38 | |
| chr8:54,463,309–54,463,781 | 3.4 kb | Proximal (<10kb) | 18 | |
| chr8:54,464,038–54,464,280 | 2.9 kb | Proximal (<10kb) | 26 | |
| chr8:54,464,390–54,464,924 | 2.3 kb | Proximal (<10kb) | 38 | |
| chr8:54,466,222–54,467,657 | at TSS | At TSS | 244 | |
| chr8:54,469,782–54,470,690 | 2.6 kb | Proximal (<10kb) | 190 | |
| chr8:54,475,602–54,476,526 | 8.4 kb | Proximal (<10kb) | 113 |
Genomic view of the ENSG00000274310 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.