Transcription factors with Perturb-seq knockdown data for ENSG00000259603. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000259603 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000259603, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:3,590,352–3,590,750 | 9.4 kb | Proximal (<10kb) | 56 | |
| chr5:3,591,008–3,591,512 | 8.7 kb | Proximal (<10kb) | 68 | |
| chr5:3,593,719–3,593,942 | 6.2 kb | Proximal (<10kb) | 17 | |
| chr5:3,594,314–3,596,993 | 3.2 kb | Proximal (<10kb) | 308 | |
| chr5:3,597,102–3,597,644 | 2.5 kb | Proximal (<10kb) | 52 | |
| chr5:3,597,938–3,598,179 | 2.0 kb | Proximal (<10kb) | 23 | |
| chr5:3,598,317–3,598,518 | 1.7 kb | Proximal (<10kb) | 27 | |
| chr5:3,598,629–3,599,113 | 1.1 kb | Proximal (<10kb) | 36 | |
| chr5:3,599,731–3,601,253 | at TSS | At TSS | 171 | |
| chr5:3,602,005–3,603,376 | 1.8 kb | Proximal (<10kb) | 201 | |
| chr5:3,606,530–3,606,746 | 6.3 kb | Proximal (<10kb) | 67 |
Genomic view of the ENSG00000259603 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.