Transcription factors with Perturb-seq knockdown data for ENSG00000257252. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000257252 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000257252, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:93,019,922–93,021,053 | 357.0 kb | Distal (>10kb) Multiome HiCAR | 563 | |
| chr12:93,022,700–93,023,746 | 354.5 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr12:93,080,230–93,081,786 | 297.2 kb | Distal (>10kb) Multiome | 272 | |
| chr12:93,087,158–93,088,100 | 290.2 kb | Distal (>10kb) Multiome HiCAR | 624 | |
| chr12:93,106,981–93,107,741 | 270.4 kb | Distal (>10kb) Multiome HiCAR | 95 | |
| chr12:93,245,335–93,245,870 | 132.1 kb | Distal (>10kb) Multiome | 155 | |
| chr12:93,370,990–93,371,306 | 6.4 kb | Proximal (<10kb) | 67 | |
| chr12:93,376,338–93,378,831 | 83 bp | At TSS Multiome | 827 | |
| chr12:93,379,761–93,380,177 | 2.0 kb | Proximal (<10kb) | 105 | |
| chr12:93,384,690–93,385,099 | 6.9 kb | Proximal (<10kb) | 13 | |
| chr12:93,441,175–93,442,781 | 64.3 kb | Distal (>10kb) Multiome | 926 | |
| chr12:93,467,156–93,468,248 | 89.8 kb | Distal (>10kb) Multiome | 844 | |
| chr12:93,569,457–93,573,628 | 193.1 kb | Distal (>10kb) Multiome | 1052 | |
| chr12:93,677,025–93,678,145 | 299.7 kb | Distal (>10kb) Multiome | 999 |
Genomic view of the ENSG00000257252 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.