This gene encodes a member of the enabled/ vasodilator-stimulated phosphoprotein. Members of this gene family are involved in actin-based motility. This protein is involved in regulating the assembly of actin filaments and modulates cell adhesion and motility. Alternate splice variants of this gene have been correlated with tumor invasiveness in certain tissues and these variants may serve as prognostic markers. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for ENAH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENAH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENAH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:225,424,635–225,425,809 | 227.9 kb | Distal (>10kb) Multiome | 399 | |
| chr1:225,427,208–225,428,777 | 225.0 kb | Distal (>10kb) Multiome | 921 | |
| chr1:225,446,105–225,447,138 | 206.6 kb | Distal (>10kb) Multiome | 178 | |
| chr1:225,474,969–225,475,612 | 178.0 kb | Distal (>10kb) Multiome HiCAR | 742 | |
| chr1:225,627,340–225,627,898 | 25.5 kb | Distal (>10kb) Multiome | 254 | |
| chr1:225,651,976–225,652,208 | 507 bp | At TSS | 266 | |
| chr1:225,652,334–225,654,131 | 104 bp | At TSS Multiome | 786 | |
| chr1:225,754,870–225,755,548 | 102.0 kb | Distal (>10kb) Multiome | 382 | |
| chr1:225,768,775–225,769,570 | 116.1 kb | Distal (>10kb) Multiome HiCAR | 313 | |
| chr1:225,771,884–225,772,638 | 119.2 kb | Distal (>10kb) Multiome HiCAR | 488 | |
| chr1:225,777,167–225,778,412 | 124.6 kb | Distal (>10kb) Multiome HiCAR | 942 | |
| chr1:225,809,711–225,811,548 | 157.0 kb | Distal (>10kb) Multiome | 654 | |
| chr1:225,845,424–225,846,556 | 192.8 kb | Distal (>10kb) Multiome | 416 | |
| chr1:225,881,255–225,884,173 | 229.2 kb | Distal (>10kb) Multiome | 879 | |
| chr1:225,888,552–225,889,596 | 236.1 kb | Distal (>10kb) Multiome | 185 | |
| chr1:225,898,735–225,899,922 | 246.4 kb | Distal (>10kb) Multiome | 335 | |
| chr1:225,903,782–225,904,454 | 250.9 kb | Distal (>10kb) Multiome | 40 | |
| chr1:225,908,825–225,909,327 | 255.9 kb | Distal (>10kb) Multiome | 101 | |
| chr1:225,910,978–225,911,799 | 258.2 kb | Distal (>10kb) Multiome | 344 | |
| chr1:225,923,776–225,924,773 | 271.2 kb | Distal (>10kb) Multiome | 960 | |
| chr1:225,939,444–225,939,998 | 286.5 kb | Distal (>10kb) Multiome | 62 | |
| chr1:225,945,518–225,946,038 | 292.6 kb | Distal (>10kb) Multiome | 172 | |
| chr1:225,948,616–225,949,435 | 295.9 kb | Distal (>10kb) Multiome | 175 |
Genomic view of the ENAH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.