Enables proteasome binding activity. Involved in ERAD pathway. Located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ECPAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ECPAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ECPAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:111,481,340–111,481,517 | 2.5 kb | Proximal (<10kb) | 22 | |
| chr9:111,482,713–111,484,706 | 1.1 kb | Proximal (<10kb) Multiome | 920 | |
| chr9:111,524,879–111,526,013 | 40.9 kb | Distal (>10kb) Multiome | 531 | |
| chr9:111,529,772–111,530,366 | 45.6 kb | Distal (>10kb) Multiome | 136 | |
| chr9:111,597,856–111,598,818 | 113.7 kb | Distal (>10kb) Multiome | 424 | |
| chr9:111,599,075–111,600,234 | 115.3 kb | Distal (>10kb) Multiome | 464 | |
| chr9:111,603,576–111,604,637 | 119.8 kb | Distal (>10kb) Multiome | 88 | |
| chr9:111,630,618–111,631,920 | 146.9 kb | Distal (>10kb) Multiome | 1034 | |
| chr9:111,660,898–111,662,420 | 177.1 kb | Distal (>10kb) Multiome | 606 | |
| chr9:111,662,977–111,663,798 | 179.1 kb | Distal (>10kb) Multiome | 132 |
Genomic view of the ECPAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.