Predicted to enable U4 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CYP1B1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYP1B1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYP1B1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:37,924,775–37,925,907 | 149.5 kb | Distal (>10kb) Multiome | 1049 | |
| chr2:38,073,535–38,077,719 | 1.7 kb | Proximal (<10kb) Multiome | 747 | |
| chr2:38,079,227–38,079,548 | 4.4 kb | Proximal (<10kb) | 48 | |
| chr2:38,084,580–38,084,949 | 9.7 kb | Proximal (<10kb) | 98 | |
| chr2:38,085,966–38,086,623 | 9.7 kb | Proximal (<10kb) | 38 | |
| chr2:38,095,584–38,097,105 | 21.3 kb | Distal (>10kb) Multiome | 485 | |
| chr2:38,105,897–38,106,254 | 9.2 kb | Proximal (<10kb) | 71 | |
| chr2:38,106,923–38,107,099 | 8.3 kb | Proximal (<10kb) | 76 | |
| chr2:38,107,792–38,108,002 | 7.4 kb | Proximal (<10kb) | 28 | |
| chr2:38,115,319–38,115,537 | at TSS | At TSS | 226 | |
| chr2:38,440,476–38,441,570 | 366.1 kb | Distal (>10kb) Multiome HiCAR | 331 | |
| chr2:38,442,985–38,445,041 | 369.8 kb | Distal (>10kb) Multiome HiCAR | 354 |
Genomic view of the CYP1B1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.