This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CYP1B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CYP1B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CYP1B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:37,924,775–37,925,907 | 150.8 kb | Distal (>10kb) Multiome | 1049 | |
| chr2:38,038,070–38,038,591 | 37.8 kb | Distal (>10kb) Multiome | 227 | |
| chr2:38,073,535–38,077,719 | 385 bp | At TSS Multiome | 747 | |
| chr2:38,079,227–38,079,548 | 8.5 kb | Proximal (<10kb) | 48 | |
| chr2:38,084,580–38,084,949 | 8.4 kb | Proximal (<10kb) | 98 | |
| chr2:38,085,966–38,086,623 | 9.8 kb | Proximal (<10kb) | 38 | |
| chr2:38,095,584–38,097,105 | 20.0 kb | Distal (>10kb) Multiome | 485 | |
| chr2:38,277,670–38,278,397 | 201.9 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr2:38,440,476–38,441,570 | 364.8 kb | Distal (>10kb) Multiome HiCAR | 331 | |
| chr2:38,442,985–38,445,041 | 368.5 kb | Distal (>10kb) Multiome HiCAR | 354 |
Genomic view of the CYP1B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.