Predicted to enable kinesin binding activity and structural molecule activity. Involved in several processes, including centriole-centriole cohesion; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in several cellular components, including actin cytoskeleton; cytosol; and microtubule organizing center. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CROCC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CROCC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CROCC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:16,534,972–16,535,673 | 386.6 kb | Distal (>10kb) Multiome HiCAR | 146 | |
| chr1:16,612,236–16,614,194 | 308.3 kb | Distal (>10kb) Multiome HiCAR | 1105 | |
| chr1:16,620,707–16,621,639 | 300.8 kb | Distal (>10kb) Multiome HiCAR | 685 | |
| chr1:16,639,254–16,639,764 | 282.4 kb | Distal (>10kb) Multiome | 46 | |
| chr1:16,644,020–16,645,162 | 277.2 kb | Distal (>10kb) Multiome | 979 | |
| chr1:16,727,237–16,727,897 | 194.5 kb | Distal (>10kb) Multiome | 430 | |
| chr1:16,872,473–16,872,975 | 49.3 kb | Distal (>10kb) Multiome | 52 | |
| chr1:16,888,814–16,889,966 | 32.4 kb | Distal (>10kb) Multiome | 224 | |
| chr1:16,895,953–16,897,630 | 25.6 kb | Distal (>10kb) Multiome | 749 | |
| chr1:16,903,833–16,905,921 | 16.8 kb | Distal (>10kb) Multiome | 1065 | |
| chr1:16,913,177–16,914,707 | 7.9 kb | Proximal (<10kb) Multiome HiCAR | 712 | |
| chr1:16,921,360–16,922,846 | 128 bp | At TSS Multiome | 315 | |
| chr1:16,938,744–16,939,855 | 17.4 kb | Distal (>10kb) Multiome HiCAR | 81 | |
| chr1:16,960,652–16,961,242 | 39.0 kb | Distal (>10kb) Multiome | 417 | |
| chr1:16,980,463–16,980,871 | 58.7 kb | Distal (>10kb) Multiome | 187 | |
| chr1:17,011,200–17,012,363 | 90.0 kb | Distal (>10kb) Multiome | 573 | |
| chr1:17,053,525–17,054,572 | 132.2 kb | Distal (>10kb) Multiome | 770 | |
| chr1:17,119,233–17,119,812 | 197.6 kb | Distal (>10kb) Multiome | 289 |
Genomic view of the CROCC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.