COPG1

coat protein complex I subunit gamma 1 | COPG

Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi apparatus. Implicated in immunodeficiency 128. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.32 Developmental clusters: GC2

Biological processes 32 terms

COPI vesicle coat (GO:0030126)COPI vesicle coat (GO:0030126)COPI vesicle coat (GO:0030126)COPI-coated vesicle membrane (GO:0030663)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)establishment of Golgi localization (GO:0051683)establishment of Golgi localization (GO:0051683)intra-Golgi vesicle-mediated transport (GO:0006891)intracellular protein transport (GO:0006886)membrane coat (GO:0030117)organelle transport along microtubule (GO:0072384)organelle transport along microtubule (GO:0072384)organelle transport along microtubule (GO:0072384)protein binding (GO:0005515)protein secretion (GO:0009306)retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum (GO:0006890)structural molecule activity (GO:0005198)transport vesicle (GO:0030133)transport vesicle (GO:0030133)vesicle-mediated transport (GO:0016192)

Expression (TPM)

TFs regulating COPG1 0 TFs

Transcription factors with Perturb-seq knockdown data for COPG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COPG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to COPG1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COPG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:128,993,367–128,994,455	255.5 kb	Distal (>10kb) Multiome	344
chr3:129,027,026–129,027,525	222.4 kb	Distal (>10kb) Multiome	589
chr3:129,045,697–129,046,752	203.0 kb	Distal (>10kb) Multiome HiCAR	170
chr3:129,120,244–129,122,947	127.6 kb	Distal (>10kb) Multiome	767
chr3:129,160,815–129,162,244	88.2 kb	Distal (>10kb) Multiome	917
chr3:129,183,284–129,184,525	65.7 kb	Distal (>10kb) Multiome	966
chr3:129,245,769–129,246,060	3.5 kb	Proximal (<10kb)	402
chr3:129,249,227–129,250,064	50 bp	At TSS Multiome	767
chr3:129,278,315–129,279,976	29.3 kb	Distal (>10kb) Multiome	767
chr3:129,305,525–129,306,095	56.2 kb	Distal (>10kb) Multiome	342
chr3:129,314,154–129,316,995	65.3 kb	Distal (>10kb) Multiome	949
chr3:129,343,720–129,344,497	94.5 kb	Distal (>10kb) Multiome	346
chr3:129,344,512–129,344,822	95.1 kb	Distal (>10kb) Multiome	58
chr3:129,359,825–129,360,642	110.8 kb	Distal (>10kb) Multiome	65
chr3:129,399,193–129,399,868	150.0 kb	Distal (>10kb) Multiome	625
chr3:129,428,173–129,429,050	179.1 kb	Distal (>10kb) Multiome	504
chr3:129,439,426–129,440,695	190.6 kb	Distal (>10kb) Multiome	875
chr3:129,534,465–129,535,515	285.3 kb	Distal (>10kb) Multiome	397

Genome Browser

Genomic view of the COPG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.