Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CLGN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLGN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLGN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:140,150,268–140,153,432 | 275.7 kb | Distal (>10kb) Multiome | 813 | |
| chr4:140,153,751–140,154,614 | 273.3 kb | Distal (>10kb) Multiome | 861 | |
| chr4:140,212,328–140,214,033 | 214.7 kb | Distal (>10kb) Multiome | 74 | |
| chr4:140,218,608–140,219,888 | 208.4 kb | Distal (>10kb) Multiome | 75 | |
| chr4:140,237,447–140,238,937 | 189.8 kb | Distal (>10kb) Multiome | 397 | |
| chr4:140,252,035–140,253,792 | 174.4 kb | Distal (>10kb) Multiome | 580 | |
| chr4:140,349,706–140,350,239 | 77.6 kb | Distal (>10kb) Multiome | 64 | |
| chr4:140,357,429–140,358,616 | 69.5 kb | Distal (>10kb) Multiome | 90 | |
| chr4:140,372,701–140,374,405 | 54.1 kb | Distal (>10kb) Multiome | 837 | |
| chr4:140,426,688–140,428,067 | 21 bp | At TSS Multiome | 896 | |
| chr4:140,515,302–140,516,703 | 88.7 kb | Distal (>10kb) Multiome | 90 | |
| chr4:140,523,657–140,524,734 | 96.5 kb | Distal (>10kb) Multiome | 865 | |
| chr4:140,567,710–140,569,432 | 141.4 kb | Distal (>10kb) Multiome | 331 | |
| chr4:140,594,849–140,595,496 | 167.6 kb | Distal (>10kb) Multiome | 205 | |
| chr4:140,640,083–140,640,873 | 212.8 kb | Distal (>10kb) Multiome | 115 |
Genomic view of the CLGN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.