CKS1B
CDC28 protein kinase regulatory subunit 1B | CKS1, ckshs1

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

Member of: DE-11 DE-11.1 Developmental clusters: GC4
Biological processes 10 terms
SCF ubiquitin ligase complex (GO:0019005)cyclin-dependent protein kinase holoenzyme complex (GO:0000307)cyclin-dependent protein serine/threonine kinase activator activity (GO:0061575)cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)histone binding (GO:0042393)nucleoplasm (GO:0005654)protein binding (GO:0005515)protein kinase binding (GO:0019901)regulation of mitotic cell cycle (GO:0007346)ubiquitin binding (GO:0043130)
Expression (TPM)
CKS1B — as a Regulated Gene

TFs regulating CKS1B 0 TFs

Transcription factors with Perturb-seq knockdown data for CKS1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CKS1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CKS1B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CKS1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:154,683,607–154,684,346 290.7 kb Distal (>10kb) Multiome 39
chr1:154,760,465–154,760,941 214.0 kb Distal (>10kb) Multiome 418
chr1:154,813,354–154,814,052 161.0 kb Distal (>10kb) Multiome 189
chr1:154,870,031–154,870,680 104.3 kb Distal (>10kb) Multiome 300
chr1:154,936,148–154,937,752 37.7 kb Distal (>10kb) Multiome 1149
chr1:154,955,571–154,956,925 18.5 kb Distal (>10kb) Multiome 504
chr1:154,961,269–154,962,529 12.9 kb Distal (>10kb) Multiome 985
chr1:154,970,161–154,971,641 3.8 kb Proximal (<10kb) Multiome 535
chr1:154,972,362–154,975,914 89 bp At TSS Multiome 1085
chr1:154,982,968–154,983,632 8.5 kb Proximal (<10kb) Multiome 693
chr1:154,998,961–155,004,423 24.6 kb Distal (>10kb) Multiome 1210
chr1:155,017,084–155,017,941 42.8 kb Distal (>10kb) Multiome 1003
chr1:155,050,292–155,052,078 76.6 kb Distal (>10kb) Multiome 948
chr1:155,061,415–155,064,552 89.2 kb Distal (>10kb) Multiome 860
chr1:155,070,748–155,071,423 96.4 kb Distal (>10kb) Multiome 542
chr1:155,078,524–155,079,535 104.1 kb Distal (>10kb) Multiome 397
chr1:155,079,852–155,081,529 106.3 kb Distal (>10kb) Multiome 539
chr1:155,084,373–155,086,501 110.4 kb Distal (>10kb) Multiome 865
chr1:155,091,315–155,091,900 116.9 kb Distal (>10kb) Multiome 594
chr1:155,126,247–155,126,903 151.8 kb Distal (>10kb) Multiome 776
chr1:155,127,607–155,128,120 153.2 kb Distal (>10kb) Multiome 578
chr1:155,135,100–155,136,750 161.2 kb Distal (>10kb) Multiome 938
chr1:155,166,847–155,168,170 193.1 kb Distal (>10kb) Multiome 622
chr1:155,172,629–155,174,979 198.6 kb Distal (>10kb) Multiome 903
chr1:155,192,921–155,194,099 218.9 kb Distal (>10kb) Multiome 755
chr1:155,194,230–155,195,403 220.2 kb Distal (>10kb) Multiome 753
chr1:155,196,127–155,196,592 221.7 kb Distal (>10kb) Multiome 97
chr1:155,207,822–155,209,789 234.3 kb Distal (>10kb) Multiome 826
chr1:155,226,522–155,227,197 251.9 kb Distal (>10kb) Multiome 600
chr1:155,227,312–155,228,116 253.0 kb Distal (>10kb) Multiome 688
chr1:155,244,103–155,245,349 270.1 kb Distal (>10kb) Multiome 900
chr1:155,250,356–155,251,199 276.2 kb Distal (>10kb) Multiome 605
chr1:155,255,032–155,255,921 280.9 kb Distal (>10kb) Multiome 661
chr1:155,261,679–155,262,788 287.7 kb Distal (>10kb) Multiome 921
chr1:155,272,928–155,274,098 298.8 kb Distal (>10kb) Multiome 768

Genome Browser

Genomic view of the CKS1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:154,673,607 – 155,284,098
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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