This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CD2AP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD2AP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD2AP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:47,181,788–47,182,605 | 295.6 kb | Distal (>10kb) Multiome | 96 | |
| chr6:47,221,406–47,222,137 | 256.0 kb | Distal (>10kb) Multiome | 105 | |
| chr6:47,308,643–47,310,418 | 167.8 kb | Distal (>10kb) Multiome | 1024 | |
| chr6:47,428,686–47,429,150 | 48.7 kb | Distal (>10kb) Multiome | 105 | |
| chr6:47,477,257–47,478,907 | 7 bp | At TSS Multiome | 1008 | |
| chr6:47,655,873–47,656,745 | 178.6 kb | Distal (>10kb) Multiome | 253 | |
| chr6:47,669,628–47,670,723 | 192.3 kb | Distal (>10kb) Multiome | 310 | |
| chr6:47,683,753–47,684,736 | 206.3 kb | Distal (>10kb) Multiome | 140 |
Genomic view of the CD2AP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.