The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for CACNG8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACNG8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACNG8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:53,772,960–53,773,600 | 189.9 kb | Distal (>10kb) Multiome | 98 | |
| chr19:53,774,097–53,775,097 | 188.3 kb | Distal (>10kb) Multiome | 24 | |
| chr19:53,792,791–53,793,343 | 169.8 kb | Distal (>10kb) Multiome | 470 | |
| chr19:53,865,880–53,866,753 | 96.7 kb | Distal (>10kb) Multiome | 532 | |
| chr19:53,866,887–53,869,891 | 95.3 kb | Distal (>10kb) Multiome | 993 | |
| chr19:53,878,918–53,880,011 | 83.4 kb | Distal (>10kb) Multiome | 561 | |
| chr19:53,881,744–53,882,458 | 80.8 kb | Distal (>10kb) Multiome | 435 | |
| chr19:53,889,715–53,890,286 | 72.9 kb | Distal (>10kb) Multiome | 322 | |
| chr19:53,898,176–53,899,412 | 64.0 kb | Distal (>10kb) Multiome | 212 | |
| chr19:53,907,868–53,908,722 | 54.6 kb | Distal (>10kb) Multiome | 276 | |
| chr19:53,941,849–53,943,229 | 20.5 kb | Distal (>10kb) Multiome | 240 | |
| chr19:53,957,309–53,957,858 | 5.4 kb | Proximal (<10kb) Multiome | 97 | |
| chr19:53,977,539–53,979,011 | 15.5 kb | Distal (>10kb) Multiome | 412 | |
| chr19:53,979,770–53,982,403 | 18.4 kb | Distal (>10kb) Multiome | 530 | |
| chr19:53,982,560–53,983,015 | 19.9 kb | Distal (>10kb) Multiome | 119 | |
| chr19:54,095,628–54,096,220 | 133.0 kb | Distal (>10kb) Multiome | 457 | |
| chr19:54,102,597–54,103,302 | 139.9 kb | Distal (>10kb) Multiome | 703 | |
| chr19:54,114,870–54,116,009 | 152.6 kb | Distal (>10kb) Multiome | 911 | |
| chr19:54,136,562–54,138,683 | 174.5 kb | Distal (>10kb) Multiome | 751 | |
| chr19:54,159,030–54,160,865 | 196.9 kb | Distal (>10kb) Multiome | 793 | |
| chr19:54,161,897–54,162,738 | 199.5 kb | Distal (>10kb) Multiome | 233 | |
| chr19:54,164,508–54,165,013 | 201.9 kb | Distal (>10kb) Multiome | 183 | |
| chr19:54,172,536–54,173,532 | 210.2 kb | Distal (>10kb) Multiome | 397 | |
| chr19:54,188,192–54,192,172 | 227.0 kb | Distal (>10kb) Multiome | 979 | |
| chr19:54,200,383–54,201,351 | 237.9 kb | Distal (>10kb) Multiome | 891 | |
| chr19:54,208,780–54,209,556 | 246.5 kb | Distal (>10kb) Multiome | 358 | |
| chr19:54,231,547–54,232,136 | 268.9 kb | Distal (>10kb) Multiome | 471 |
Genomic view of the CACNG8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.