The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CACNA1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACNA1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACNA1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:137,578,523–137,579,553 | 298.8 kb | Distal (>10kb) Multiome | 910 | |
| chr9:137,589,526–137,591,323 | 287.2 kb | Distal (>10kb) Multiome | 623 | |
| chr9:137,604,440–137,607,003 | 272.3 kb | Distal (>10kb) Multiome | 675 | |
| chr9:137,618,064–137,619,880 | 258.8 kb | Distal (>10kb) Multiome | 867 | |
| chr9:137,723,975–137,724,439 | 153.6 kb | Distal (>10kb) Multiome | 115 | |
| chr9:137,732,255–137,733,025 | 145.1 kb | Distal (>10kb) Multiome | 20 | |
| chr9:137,851,599–137,852,229 | 25.9 kb | Distal (>10kb) Multiome | 104 | |
| chr9:137,876,903–137,879,307 | 155 bp | At TSS Multiome | 452 | |
| chr9:138,022,374–138,023,958 | 144.9 kb | Distal (>10kb) Multiome | 247 | |
| chr9:138,033,660–138,034,441 | 156.3 kb | Distal (>10kb) Multiome | 195 |
Genomic view of the CACNA1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.