The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BTBD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTBD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTBD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,725,307–1,726,101 | 309.1 kb | Distal (>10kb) Multiome | 455 | |
| chr19:1,811,638–1,813,347 | 222.3 kb | Distal (>10kb) Multiome | 782 | |
| chr19:1,826,853–1,827,379 | 207.6 kb | Distal (>10kb) Multiome | 193 | |
| chr19:1,848,048–1,848,953 | 186.2 kb | Distal (>10kb) Multiome | 819 | |
| chr19:1,851,701–1,852,216 | 182.9 kb | Distal (>10kb) Multiome | 115 | |
| chr19:1,855,082–1,856,620 | 179.4 kb | Distal (>10kb) Multiome | 476 | |
| chr19:1,861,439–1,865,723 | 170.9 kb | Distal (>10kb) Multiome | 891 | |
| chr19:1,875,645–1,876,693 | 158.6 kb | Distal (>10kb) Multiome | 887 | |
| chr19:1,885,058–1,885,861 | 149.3 kb | Distal (>10kb) Multiome | 495 | |
| chr19:1,904,556–1,906,084 | 129.4 kb | Distal (>10kb) Multiome | 907 | |
| chr19:1,940,240–1,942,987 | 93.9 kb | Distal (>10kb) Multiome | 901 | |
| chr19:2,015,095–2,015,793 | at TSS | At TSS | 260 | |
| chr19:2,016,050–2,016,343 | 336 bp | At TSS | 170 | |
| chr19:2,021,378–2,021,809 | 5.7 kb | Proximal (<10kb) | 50 | |
| chr19:2,034,637–2,035,967 | 198 bp | At TSS Multiome | 368 | |
| chr19:2,041,744–2,042,811 | 7.3 kb | Proximal (<10kb) Multiome | 586 | |
| chr19:2,049,171–2,052,365 | 16.4 kb | Distal (>10kb) Multiome | 977 | |
| chr19:2,060,703–2,062,560 | 26.7 kb | Distal (>10kb) Multiome | 913 | |
| chr19:2,095,898–2,097,954 | 61.8 kb | Distal (>10kb) Multiome | 945 | |
| chr19:2,150,726–2,152,200 | 116.9 kb | Distal (>10kb) Multiome | 761 | |
| chr19:2,163,561–2,164,587 | 129.0 kb | Distal (>10kb) Multiome | 750 | |
| chr19:2,235,315–2,237,253 | 201.7 kb | Distal (>10kb) Multiome | 1119 | |
| chr19:2,269,007–2,271,589 | 234.5 kb | Distal (>10kb) Multiome | 983 | |
| chr19:2,273,467–2,274,136 | 238.9 kb | Distal (>10kb) Multiome | 825 | |
| chr19:2,327,828–2,329,150 | 293.7 kb | Distal (>10kb) Multiome | 759 |
Genomic view of the BTBD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.