Enables identical protein binding activity. Predicted to be located in azurophil granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BRI3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRI3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRI3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:97,971,853–97,972,772 | 280.2 kb | Distal (>10kb) Multiome | 763 | |
| chr7:97,973,121–97,973,850 | 278.8 kb | Distal (>10kb) Multiome | 130 | |
| chr7:98,034,095–98,034,783 | 217.8 kb | Distal (>10kb) Multiome | 131 | |
| chr7:98,051,142–98,051,601 | 201.1 kb | Distal (>10kb) Multiome | 248 | |
| chr7:98,106,660–98,107,619 | 145.5 kb | Distal (>10kb) Multiome | 870 | |
| chr7:98,251,470–98,252,647 | 198 bp | At TSS Multiome | 846 | |
| chr7:98,280,710–98,282,616 | 29.1 kb | Distal (>10kb) Multiome | 691 | |
| chr7:98,287,322–98,288,019 | 5.6 kb | Proximal (<10kb) | 153 | |
| chr7:98,294,739–98,295,296 | 42.6 kb | Distal (>10kb) Multiome | 363 | |
| chr7:98,305,831–98,306,470 | 53.8 kb | Distal (>10kb) Multiome | 55 | |
| chr7:98,362,631–98,363,114 | 110.5 kb | Distal (>10kb) Multiome | 59 | |
| chr7:98,400,423–98,401,663 | 148.8 kb | Distal (>10kb) Multiome HiCAR | 752 | |
| chr7:98,470,267–98,471,178 | 218.4 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the BRI3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.