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DE-1.29

Submodule 16 genes

Antioxidant and ubiquitin-proteasome pathway components

This module contains 16 genes including GPX1, GPX4, NEDD8, and SKP1, enriched for antioxidant activity, ubiquitin conjugation, and proteasomal protein degradation processes. No transcription factor knockdown data are available for this module, preventing assessment of upstream regulatory control during the differentiation process.

Key terms: lipoxygenase pathway response to selenium ion arachidonate metabolic process Notable genes: GPX1 GPX4 NEDD8 LAMTOR5 SKP1 LAMTOR1 SELENOW NME4

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (16)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z
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