Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARHGEF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARHGEF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARHGEF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:156,746,390–156,748,386 | 298.5 kb | Distal (>10kb) Multiome | 750 | |
| chr1:156,751,012–156,752,594 | 293.9 kb | Distal (>10kb) Multiome | 869 | |
| chr1:156,766,695–156,768,280 | 278.4 kb | Distal (>10kb) Multiome | 967 | |
| chr1:156,813,606–156,814,470 | 231.7 kb | Distal (>10kb) Multiome | 756 | |
| chr1:156,845,268–156,845,794 | 200.2 kb | Distal (>10kb) Multiome | 73 | |
| chr1:156,848,614–156,849,138 | 196.8 kb | Distal (>10kb) Multiome | 129 | |
| chr1:156,860,147–156,861,294 | 185.1 kb | Distal (>10kb) Multiome | 484 | |
| chr1:156,862,753–156,863,585 | 182.5 kb | Distal (>10kb) Multiome | 268 | |
| chr1:156,892,162–156,892,597 | 153.3 kb | Distal (>10kb) Multiome | 439 | |
| chr1:156,893,409–156,893,975 | 151.9 kb | Distal (>10kb) Multiome | 143 | |
| chr1:156,920,128–156,921,047 | 125.2 kb | Distal (>10kb) Multiome | 508 | |
| chr1:156,927,257–156,928,255 | 117.9 kb | Distal (>10kb) Multiome | 424 | |
| chr1:156,996,881–156,997,694 | 48.4 kb | Distal (>10kb) Multiome | 167 | |
| chr1:157,045,268–157,046,656 | 166 bp | At TSS Multiome | 678 | |
| chr1:157,050,158–157,050,444 | 4.4 kb | Proximal (<10kb) | 11 | |
| chr1:157,050,690–157,051,299 | 4.9 kb | Proximal (<10kb) | 32 | |
| chr1:157,074,275–157,074,755 | 28.7 kb | Distal (>10kb) Multiome | 204 | |
| chr1:157,137,885–157,139,148 | 92.8 kb | Distal (>10kb) Multiome | 882 | |
| chr1:157,155,672–157,156,657 | 110.4 kb | Distal (>10kb) Multiome | 435 | |
| chr1:157,162,009–157,162,557 | 116.4 kb | Distal (>10kb) Multiome | 87 | |
| chr1:157,163,342–157,163,961 | 118.0 kb | Distal (>10kb) Multiome | 272 | |
| chr1:157,310,515–157,311,882 | 265.6 kb | Distal (>10kb) Multiome | 209 |
Genomic view of the ARHGEF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.