Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for ACTG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACTG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACTG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,222,360–81,223,690 | 289.6 kb | Distal (>10kb) Multiome | 861 | |
| chr17:81,238,602–81,239,760 | 273.6 kb | Distal (>10kb) Multiome | 811 | |
| chr17:81,295,024–81,295,658 | 217.5 kb | Distal (>10kb) Multiome | 832 | |
| chr17:81,339,311–81,340,470 | 173.3 kb | Distal (>10kb) Multiome | 474 | |
| chr17:81,345,409–81,347,165 | 166.6 kb | Distal (>10kb) Multiome | 891 | |
| chr17:81,393,141–81,395,575 | 118.8 kb | Distal (>10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 115.4 kb | Distal (>10kb) Multiome | 646 | |
| chr17:81,481,258–81,481,865 | 31.2 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 28.4 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 24.8 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 126 bp | At TSS Multiome | 1116 | |
| chr17:81,518,632–81,519,878 | 6.7 kb | Proximal (<10kb) Multiome | 617 | |
| chr17:81,537,462–81,537,907 | 24.9 kb | Distal (>10kb) Multiome | 282 | |
| chr17:81,551,821–81,553,314 | 40.4 kb | Distal (>10kb) Multiome | 845 | |
| chr17:81,636,404–81,637,301 | 124.2 kb | Distal (>10kb) Multiome | 946 | |
| chr17:81,648,048–81,648,550 | 135.5 kb | Distal (>10kb) Multiome | 88 | |
| chr17:81,652,970–81,653,572 | 140.4 kb | Distal (>10kb) Multiome | 188 | |
| chr17:81,666,251–81,667,166 | 153.9 kb | Distal (>10kb) Multiome | 901 | |
| chr17:81,683,344–81,684,556 | 171.1 kb | Distal (>10kb) Multiome | 926 | |
| chr17:81,702,879–81,703,868 | 190.6 kb | Distal (>10kb) Multiome | 981 | |
| chr17:81,711,721–81,712,812 | 199.4 kb | Distal (>10kb) Multiome | 1056 |
Genomic view of the ACTG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.