The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACBD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACBD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACBD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:225,888,552–225,889,596 | 297.5 kb | Distal (>10kb) Multiome | 185 | |
| chr1:225,898,735–225,899,922 | 287.2 kb | Distal (>10kb) Multiome | 335 | |
| chr1:225,903,782–225,904,454 | 282.7 kb | Distal (>10kb) Multiome | 40 | |
| chr1:225,908,825–225,909,327 | 277.7 kb | Distal (>10kb) Multiome | 101 | |
| chr1:225,910,978–225,911,799 | 275.4 kb | Distal (>10kb) Multiome | 344 | |
| chr1:225,923,776–225,924,773 | 262.4 kb | Distal (>10kb) Multiome | 960 | |
| chr1:225,939,444–225,939,998 | 247.1 kb | Distal (>10kb) Multiome | 62 | |
| chr1:225,945,518–225,946,038 | 241.0 kb | Distal (>10kb) Multiome | 172 | |
| chr1:225,948,616–225,949,435 | 237.7 kb | Distal (>10kb) Multiome | 175 | |
| chr1:225,957,776–225,958,797 | 228.4 kb | Distal (>10kb) Multiome | 175 | |
| chr1:225,999,043–226,000,159 | 187.2 kb | Distal (>10kb) Multiome | 969 | |
| chr1:226,061,587–226,063,333 | 124.2 kb | Distal (>10kb) Multiome | 976 | |
| chr1:226,082,913–226,084,135 | 103.1 kb | Distal (>10kb) Multiome | 852 | |
| chr1:226,109,567–226,111,083 | 76.7 kb | Distal (>10kb) Multiome | 768 | |
| chr1:226,121,192–226,122,943 | 64.9 kb | Distal (>10kb) Multiome | 840 | |
| chr1:226,125,045–226,125,680 | 61.4 kb | Distal (>10kb) Multiome | 373 | |
| chr1:226,186,167–226,187,132 | 54 bp | At TSS Multiome | 939 | |
| chr1:226,210,358–226,211,556 | 24.2 kb | Distal (>10kb) Multiome | 262 | |
| chr1:226,214,653–226,215,688 | 28.7 kb | Distal (>10kb) Multiome | 145 | |
| chr1:226,222,744–226,224,297 | 36.7 kb | Distal (>10kb) Multiome | 635 | |
| chr1:226,227,753–226,229,876 | 41.7 kb | Distal (>10kb) Multiome | 240 | |
| chr1:226,308,507–226,309,932 | 122.5 kb | Distal (>10kb) Multiome | 915 | |
| chr1:226,404,588–226,405,519 | 218.4 kb | Distal (>10kb) Multiome | 185 | |
| chr1:226,407,433–226,408,738 | 221.4 kb | Distal (>10kb) Multiome | 894 | |
| chr1:226,413,963–226,414,602 | 227.5 kb | Distal (>10kb) Multiome | 41 |
Genomic view of the ACBD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.