This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for ABR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:927,652–928,423 | 252.1 kb | Distal (>10kb) Multiome | 315 | |
| chr17:933,255–933,971 | 246.4 kb | Distal (>10kb) Multiome | 400 | |
| chr17:951,413–952,178 | 228.2 kb | Distal (>10kb) Multiome | 385 | |
| chr17:964,907–965,931 | 214.4 kb | Distal (>10kb) Multiome | 256 | |
| chr17:978,189–980,530 | 200.1 kb | Distal (>10kb) Multiome | 639 | |
| chr17:996,479–997,532 | 183.1 kb | Distal (>10kb) Multiome | 994 | |
| chr17:1,031,608–1,032,193 | 148.1 kb | Distal (>10kb) Multiome | 54 | |
| chr17:1,109,073–1,109,822 | 70.4 kb | Distal (>10kb) Multiome | 401 | |
| chr17:1,179,265–1,180,687 | 67 bp | At TSS Multiome | 303 | |
| chr17:1,181,418–1,181,863 | 1.4 kb | Proximal (<10kb) | 142 | |
| chr17:1,187,041–1,187,512 | 7.4 kb | Proximal (<10kb) Multiome | 361 | |
| chr17:1,202,976–1,204,162 | 23.5 kb | Distal (>10kb) Multiome | 420 | |
| chr17:1,210,129–1,211,219 | 30.7 kb | Distal (>10kb) Multiome | 35 | |
| chr17:1,268,002–1,268,635 | 88.3 kb | Distal (>10kb) Multiome | 644 | |
| chr17:1,399,339–1,400,718 | 220.3 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,455,335–1,456,916 | 276.4 kb | Distal (>10kb) Multiome | 879 |
Genomic view of the ABR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.