Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HMOX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HMOX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HMOX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:35,257,329–35,258,076 | 123.5 kb | Distal (>10kb) Multiome | 851 | |
| chr22:35,299,271–35,300,787 | 81.1 kb | Distal (>10kb) Multiome | 908 | |
| chr22:35,350,767–35,351,264 | 30.1 kb | Distal (>10kb) Multiome | 589 | |
| chr22:35,371,784–35,372,565 | 9.0 kb | Proximal (<10kb) Multiome | 874 | |
| chr22:35,376,743–35,377,378 | 4.1 kb | Proximal (<10kb) Multiome | 810 | |
| chr22:35,377,498–35,377,915 | 3.2 kb | Proximal (<10kb) | 110 | |
| chr22:35,379,010–35,379,381 | 1.7 kb | Proximal (<10kb) | 137 | |
| chr22:35,380,952–35,381,367 | at TSS | At TSS | 670 | |
| chr22:35,399,845–35,400,552 | 18.9 kb | Distal (>10kb) Multiome | 740 | |
| chr22:35,539,918–35,540,941 | 159.4 kb | Distal (>10kb) Multiome | 411 | |
| chr22:35,627,232–35,627,966 | 246.6 kb | Distal (>10kb) Multiome | 482 |
Genomic view of the HMOX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.