Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for KDR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KDR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KDR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:54,986,173–54,986,703 | 139.2 kb | Distal (>10kb) Multiome | 116 | |
| chr4:55,036,296–55,037,282 | 88.9 kb | Distal (>10kb) Multiome | 105 | |
| chr4:55,116,522–55,116,813 | 8.8 kb | Proximal (<10kb) | 47 | |
| chr4:55,124,658–55,126,127 | 13 bp | At TSS Multiome | 263 | |
| chr4:55,132,777–55,133,105 | 7.2 kb | Proximal (<10kb) | 53 | |
| chr4:55,169,439–55,169,958 | 44.1 kb | Distal (>10kb) Multiome | 88 | |
| chr4:55,256,726–55,257,189 | 131.4 kb | Distal (>10kb) Multiome | 74 | |
| chr4:55,280,261–55,281,766 | 155.8 kb | Distal (>10kb) Multiome | 162 | |
| chr4:55,346,084–55,347,178 | 220.8 kb | Distal (>10kb) Multiome | 874 | |
| chr4:55,395,297–55,396,739 | 270.3 kb | Distal (>10kb) Multiome | 882 |
Genomic view of the KDR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.