This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
Transcription factors with Perturb-seq knockdown data for PTK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:141,000,143–141,002,200 | 65 bp | At TSS Multiome | 899 | |
| chr8:141,016,712–141,017,668 | 15.8 kb | Distal (>10kb) Multiome | 80 | |
| chr8:141,026,596–141,027,291 | 25.7 kb | Distal (>10kb) Multiome | 443 | |
| chr8:141,075,037–141,076,064 | 74.3 kb | Distal (>10kb) Multiome | 517 | |
| chr8:141,084,176–141,084,832 | 83.2 kb | Distal (>10kb) Multiome | 417 | |
| chr8:141,127,643–141,129,710 | 127.2 kb | Distal (>10kb) Multiome | 851 |
Genomic view of the PTK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.