This gene encodes a resident endoplasmic reticulum (ER) protein that functions in N-glycan recognition. This protein is thought to be involved in ER-associated degradation via its interaction with the membrane-associated ubiquitin ligase complex. It also functions as a regulator of multiple cellular stress-response pathways in a manner that promotes metastatic cell survival. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 21. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for ERLEC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ERLEC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ERLEC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:53,767,422–53,768,367 | 19.1 kb | Distal (>10kb) Multiome | 710 | |
| chr2:53,786,365–53,787,886 | 46 bp | At TSS Multiome | 999 | |
| chr2:53,859,343–53,860,396 | 72.9 kb | Distal (>10kb) Multiome | 238 | |
| chr2:53,970,071–53,971,956 | 184.1 kb | Distal (>10kb) Multiome | 992 | |
| chr2:53,973,080–53,973,900 | 186.5 kb | Distal (>10kb) Multiome | 37 |
Genomic view of the ERLEC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.