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DE-6.8

Submodule 19 genes

Cell cycle positive regulation and DNA repair

This 19-gene module includes FANCD2, RAD18, LIG1, and CDC7, with enrichment in positive regulation of cell cycle process and regulation of cell cycle. Knockdown of MESP1, GATA4, and SOX17 activates this module. Knockdown of NANOG, POU5F1, and OCT4 represses this module.

Key terms: cell cycle process cell cycle positive regulation of cell cycle process regulation of cell cycle process Notable genes: FANCD2 RAD18 LIG1 CDC7 KCNQ3 CENPJ RBL1 MCM8

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (19)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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