The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RAD18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAD18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAD18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:8,663,020–8,663,944 | 299.9 kb | Distal (>10kb) Multiome | 393 | |
| chr3:8,714,000–8,714,720 | 249.1 kb | Distal (>10kb) Multiome | 121 | |
| chr3:8,741,383–8,742,278 | 221.7 kb | Distal (>10kb) Multiome | 328 | |
| chr3:8,767,641–8,768,551 | 195.5 kb | Distal (>10kb) Multiome | 241 | |
| chr3:8,768,956–8,769,996 | 194.0 kb | Distal (>10kb) Multiome HiCAR | 494 | |
| chr3:8,882,072–8,882,855 | 81.1 kb | Distal (>10kb) Multiome | 91 | |
| chr3:8,962,788–8,963,860 | 14 bp | At TSS Multiome | 759 | |
| chr3:8,964,535–8,964,701 | 1.1 kb | Proximal (<10kb) | 66 | |
| chr3:8,987,645–8,988,416 | 24.5 kb | Distal (>10kb) Multiome | 298 | |
| chr3:9,101,985–9,102,991 | 139.1 kb | Distal (>10kb) Multiome | 210 | |
| chr3:9,135,686–9,136,655 | 172.8 kb | Distal (>10kb) Multiome | 201 | |
| chr3:9,158,726–9,159,822 | 195.9 kb | Distal (>10kb) Multiome | 115 | |
| chr3:9,204,163–9,205,101 | 241.1 kb | Distal (>10kb) Multiome | 389 | |
| chr3:9,249,284–9,250,085 | 286.2 kb | Distal (>10kb) Multiome | 452 | |
| chr3:9,302,190–9,302,888 | 339.2 kb | Distal (>10kb) Multiome HiCAR | 416 |
Genomic view of the RAD18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.