This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for CENPJ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CENPJ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CENPJ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:24,680,076–24,681,056 | 242.3 kb | Distal (>10kb) Multiome | 266 | |
| chr13:24,714,126–24,714,653 | 208.4 kb | Distal (>10kb) Multiome | 40 | |
| chr13:24,715,820–24,716,895 | 206.5 kb | Distal (>10kb) Multiome | 147 | |
| chr13:24,746,528–24,747,148 | 175.9 kb | Distal (>10kb) Multiome | 140 | |
| chr13:24,922,363–24,923,209 | 115 bp | At TSS Multiome | 771 | |
| chr13:24,931,823–24,932,053 | 9.0 kb | Proximal (<10kb) | 70 | |
| chr13:25,047,042–25,047,668 | 124.4 kb | Distal (>10kb) Multiome | 177 | |
| chr13:25,170,532–25,171,326 | 248.1 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the CENPJ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.