A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for PRRC2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRRC2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRRC2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,366,884–31,367,398 | 253.6 kb | Distal (>10kb) Multiome | 433 | |
| chr6:31,399,631–31,400,231 | 220.9 kb | Distal (>10kb) Multiome | 678 | |
| chr6:31,403,046–31,404,269 | 217.1 kb | Distal (>10kb) Multiome | 796 | |
| chr6:31,441,682–31,442,105 | 178.9 kb | Distal (>10kb) Multiome | 316 | |
| chr6:31,462,703–31,463,323 | 157.6 kb | Distal (>10kb) Multiome | 352 | |
| chr6:31,497,638–31,498,615 | 122.7 kb | Distal (>10kb) Multiome | 613 | |
| chr6:31,541,205–31,542,816 | 78.6 kb | Distal (>10kb) Multiome HiCAR | 1073 | |
| chr6:31,546,485–31,547,136 | 74.0 kb | Distal (>10kb) Multiome HiCAR | 589 | |
| chr6:31,547,301–31,547,742 | 73.1 kb | Distal (>10kb) Multiome HiCAR | 762 | |
| chr6:31,580,713–31,581,330 | 39.7 kb | Distal (>10kb) Multiome | 745 | |
| chr6:31,619,744–31,621,435 | 176 bp | At TSS Multiome | 1127 | |
| chr6:31,651,682–31,653,297 | 32.0 kb | Distal (>10kb) Multiome | 1113 | |
| chr6:31,660,325–31,660,941 | 40.1 kb | Distal (>10kb) Multiome | 892 | |
| chr6:31,664,725–31,666,373 | 44.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr6:31,682,887–31,683,880 | 62.6 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,702,816–31,703,520 | 82.6 kb | Distal (>10kb) Multiome | 875 | |
| chr6:31,713,576–31,714,641 | 93.4 kb | Distal (>10kb) Multiome | 171 | |
| chr6:31,728,852–31,730,814 | 109.5 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,739,236–31,740,741 | 119.2 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:31,766,045–31,766,778 | 145.7 kb | Distal (>10kb) Multiome | 351 | |
| chr6:31,795,097–31,796,366 | 175.2 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,806,162–31,807,183 | 186.2 kb | Distal (>10kb) Multiome | 947 | |
| chr6:31,814,125–31,815,936 | 193.9 kb | Distal (>10kb) Multiome | 822 | |
| chr6:31,818,020–31,818,663 | 197.7 kb | Distal (>10kb) Multiome | 280 | |
| chr6:31,821,306–31,822,544 | 201.3 kb | Distal (>10kb) Multiome | 714 | |
| chr6:31,826,770–31,828,135 | 206.8 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:31,834,277–31,835,371 | 214.0 kb | Distal (>10kb) Multiome | 1085 | |
| chr6:31,862,148–31,864,173 | 242.2 kb | Distal (>10kb) Multiome | 1118 | |
| chr6:31,896,965–31,898,037 | 276.9 kb | Distal (>10kb) Multiome | 654 | |
| chr6:31,901,114–31,902,643 | 281.5 kb | Distal (>10kb) Multiome | 826 |
Genomic view of the PRRC2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.