Enables microtubule binding activity. Involved in centriole replication and centriole-centriole cohesion. Located in cytosol and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEP44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:173,521,529–173,524,247 | 761.2 kb | Distal (>10kb) Multiome HiCAR | 413 | |
| chr4:174,213,405–174,215,117 | 69.1 kb | Distal (>10kb) Multiome | 337 | |
| chr4:174,282,908–174,284,505 | 137 bp | At TSS Multiome | 910 | |
| chr4:174,284,609–174,284,742 | 880 bp | At TSS | 90 | |
| chr4:174,402,431–174,403,641 | 119.3 kb | Distal (>10kb) Multiome | 211 | |
| chr4:174,521,789–174,523,574 | 238.8 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the CEP44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.