This 27-gene module includes HDAC4, TRPM7, DLG1, PPP3CA, and NFIB, with enrichment for neuron projection and synapse terms. Knockdown of SMAD3, ARID1A, and MIXL1 activates this module. Knockdown of SMAD5, SOX4, and DR1 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.