This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for PUM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PUM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PUM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:20,050,661–20,052,578 | 298.8 kb | Distal (>10kb) Multiome | 1029 | |
| chr2:20,097,914–20,098,555 | 252.3 kb | Distal (>10kb) Multiome | 480 | |
| chr2:20,106,361–20,107,468 | 243.8 kb | Distal (>10kb) Multiome | 181 | |
| chr2:20,207,998–20,208,855 | 142.3 kb | Distal (>10kb) Multiome | 346 | |
| chr2:20,223,290–20,226,136 | 127.0 kb | Distal (>10kb) Multiome | 1023 | |
| chr2:20,242,059–20,243,494 | 108.2 kb | Distal (>10kb) Multiome | 372 | |
| chr2:20,344,816–20,345,233 | 5.1 kb | Proximal (<10kb) | 11 | |
| chr2:20,348,437–20,348,967 | 1.3 kb | Proximal (<10kb) | 256 | |
| chr2:20,350,092–20,352,594 | 201 bp | At TSS Multiome | 1127 | |
| chr2:20,353,589–20,354,039 | 3.3 kb | Proximal (<10kb) | 108 | |
| chr2:20,446,303–20,448,812 | 96.3 kb | Distal (>10kb) Multiome | 1072 | |
| chr2:20,510,011–20,510,507 | 159.5 kb | Distal (>10kb) Multiome | 307 | |
| chr2:20,524,538–20,525,515 | 174.2 kb | Distal (>10kb) Multiome | 598 | |
| chr2:20,635,654–20,636,525 | 285.3 kb | Distal (>10kb) Multiome HiCAR | 590 | |
| chr2:20,642,270–20,642,905 | 291.9 kb | Distal (>10kb) Multiome HiCAR | 430 | |
| chr2:20,650,354–20,651,898 | 300.5 kb | Distal (>10kb) Multiome | 916 |
Genomic view of the PUM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.