Enables several functions, including ATPase binding activity; calmodulin binding activity; and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; negative regulation of angiotensin-activated signaling pathway; and peptidyl-serine dephosphorylation. Located in cytoplasm; cytoplasmic side of plasma membrane; and dendritic spine. Part of calcineurin complex. Implicated in developmental and epileptic encephalopathy 91. Biomarker of cholangiocarcinoma; focal segmental glomerulosclerosis; and schizophrenia. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPP3CA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP3CA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP3CA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:101,114,829–101,115,431 | 232.3 kb | Distal (>10kb) Multiome | 336 | |
| chr4:101,152,402–101,153,947 | 194.6 kb | Distal (>10kb) Multiome | 157 | |
| chr4:101,282,161–101,282,877 | 64.9 kb | Distal (>10kb) Multiome | 222 | |
| chr4:101,338,485–101,338,734 | 8.8 kb | Proximal (<10kb) | 35 | |
| chr4:101,345,356–101,348,852 | 221 bp | At TSS Multiome | 986 | |
| chr4:101,464,187–101,465,046 | 117.3 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the PPP3CA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.