DLG1
discs large MAGUK scaffold protein 1 | DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gene. [provided by RefSeq, Sep 2018]

Member of: DE-3 DE-3.6
Biological processes 116 terms
GDP metabolic process (GO:0046710)GMP kinase activity (GO:0004385)GMP metabolic process (GO:0046037)Golgi apparatus (GO:0005794)L27 domain binding (GO:0097016)MPP7-DLG1-LIN7 complex (GO:0097025)actin filament organization (GO:0007015)adherens junction (GO:0005912)anchoring junction (GO:0070161)apical plasma membrane (GO:0016324)astral microtubule organization (GO:0030953)basement membrane (GO:0005604)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)bicellular tight junction (GO:0005923)bicellular tight junction assembly (GO:0070830)cadherin binding (GO:0045296)cell junction (GO:0030054)cell junction (GO:0030054)cell projection membrane (GO:0031253)cell-cell adhesion (GO:0098609)cell-cell adhesion (GO:0098609)cell-cell junction (GO:0005911)chemical synaptic transmission (GO:0007268)chemical synaptic transmission (GO:0007268)cortical actin cytoskeleton organization (GO:0030866)cortical microtubule organization (GO:0043622)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytoskeletal protein binding (GO:0008092)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endothelial cell proliferation (GO:0001935)establishment of centrosome localization (GO:0051660)establishment or maintenance of cell polarity (GO:0007163)establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)extracellular exosome (GO:0070062)glutamatergic synapse (GO:0098978)immunological synapse (GO:0001772)immunological synapse (GO:0001772)immunological synapse (GO:0001772)intercalated disc (GO:0014704)ionotropic glutamate receptor binding (GO:0035255)kinase binding (GO:0019900)kinase binding (GO:0019900)lateral loop (GO:0043219)lateral plasma membrane (GO:0016328)maintenance of postsynaptic density structure (GO:0099562)membrane raft (GO:0045121)membrane repolarization during ventricular cardiac muscle cell action potential (GO:0098915)membrane repolarization during ventricular cardiac muscle cell action potential (GO:0098915)microtubule (GO:0005874)molecular adaptor activity (GO:0060090)myelin sheath abaxonal region (GO:0035748)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)negative regulation of p38MAPK cascade (GO:1903753)negative regulation of transcription by RNA polymerase II (GO:0000122)nervous system development (GO:0007399)neuromuscular junction (GO:0031594)neuromuscular junction (GO:0031594)neuron projection (GO:0043005)neuron projection (GO:0043005)neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645)node of Ranvier (GO:0033268)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)phosphatase binding (GO:0019902)phosphoprotein phosphatase activity (GO:0004721)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of potassium ion transport (GO:0043268)positive regulation of protein localization to plasma membrane (GO:1903078)postsynaptic density (GO:0014069)postsynaptic density membrane (GO:0098839)potassium channel regulator activity (GO:0015459)potassium channel regulator activity (GO:0015459)potassium channel regulator activity (GO:0015459)potassium channel regulator activity (GO:0015459)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein localization to cell periphery (GO:1990778)protein localization to membrane (GO:0072657)protein localization to plasma membrane (GO:0072659)protein localization to plasma membrane (GO:0072659)protein localization to synapse (GO:0035418)protein-containing complex localization (GO:0031503)protein-containing complex localization (GO:0031503)receptor clustering (GO:0043113)receptor localization to synapse (GO:0097120)regulation of cell shape (GO:0008360)regulation of membrane potential (GO:0042391)regulation of non-canonical NF-kappaB signal transduction (GO:1901222)regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)regulation of potassium ion export across plasma membrane (GO:1903764)regulation of potassium ion export across plasma membrane (GO:1903764)regulation of potassium ion import (GO:1903286)regulation of potassium ion import (GO:1903286)regulation of potassium ion transport (GO:0043266)regulation of protein localization (GO:0032880)regulation of protein localization to synapse (GO:1902473)regulation of protein localization to synapse (GO:1902473)regulation of sodium ion transmembrane transport (GO:1902305)regulation of ventricular cardiac muscle cell action potential (GO:0098911)regulation of ventricular cardiac muscle cell action potential (GO:0098911)sarcolemma (GO:0042383)structural constituent of postsynaptic density (GO:0098919)synapse (GO:0045202)synaptic membrane (GO:0097060)synaptic membrane (GO:0097060)transmembrane transporter binding (GO:0044325)
Expression (TPM)
DLG1 — as a Regulated Gene

TFs regulating DLG1 0 TFs

Transcription factors with Perturb-seq knockdown data for DLG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to DLG1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr3:197,002,398–197,004,003 295.5 kb Distal (>10kb) Multiome 569
chr3:197,028,743–197,030,204 268.7 kb Distal (>10kb) Multiome 646
chr3:197,297,490–197,299,437 293 bp At TSS Multiome 941
chr3:197,464,855–197,465,525 166.5 kb Distal (>10kb) Multiome HiCAR 302
chr3:197,509,884–197,510,593 211.7 kb Distal (>10kb) Multiome 656
chr3:197,527,591–197,529,092 229.8 kb Distal (>10kb) Multiome 184
chr3:197,540,773–197,541,383 242.5 kb Distal (>10kb) Multiome 172
chr3:197,541,675–197,542,327 243.4 kb Distal (>10kb) Multiome 188
chr3:197,547,230–197,547,930 249.0 kb Distal (>10kb) Multiome 223
chr3:197,554,469–197,556,297 257.6 kb Distal (>10kb) Multiome 577
chr3:197,573,028–197,573,650 274.7 kb Distal (>10kb) Multiome 442

Genome Browser

Genomic view of the DLG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr3:196,992,398 – 197,583,650
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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