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DE-3.44

Submodule 10 genes

B-cell receptor and immunoglobulin signaling

This module contains 10 genes including BCR, TNFRSF11A, SEPTIN9, XYLT1, and WLS, enriched for B-cell receptor signaling and immunoglobulin-related processes. Knockdown of ARID1A activates this module. Knockdown of SOX11 represses this module.

Key terms: regulation of Wnt protein secretion positive regulation of heat generation circadian temperature homeostasis regulation of heat generation Notable genes: BCR TNFRSF11A SEPTIN9 XYLT1 WLS ZMIZ1 DNAJC6 GLIS1 Top TFs: ARID1A SOX11

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (10)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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