Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. Implicated in Zaki syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WLS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WLS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WLS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:68,230,339–68,230,952 | 1.6 kb | Proximal (<10kb) | 152 | |
| chr1:68,231,101–68,233,483 | 75 bp | At TSS Multiome | 557 | |
| chr1:68,240,130–68,240,368 | 7.6 kb | Proximal (<10kb) | 5 | |
| chr1:68,276,130–68,277,060 | 44.1 kb | Distal (>10kb) Multiome | 216 | |
| chr1:68,293,575–68,295,170 | 61.7 kb | Distal (>10kb) Multiome | 309 | |
| chr1:68,496,039–68,497,758 | 264.6 kb | Distal (>10kb) Multiome | 831 | |
| chr1:70,204,918–70,206,272 | 1973.1 kb | Distal (>10kb) Multiome HiCAR | 947 |
Genomic view of the WLS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.