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DE-3.42

Submodule 11 genes

Centrosome and DNA damage response factors

Module DE-3.42 contains 11 genes including NUMA1, FANCM, PCNT, and CEP43, with enrichment in centrosome organization and DNA repair pathways. Knockdown of SMAD3 and ARID1A activates this module. Knockdown of SOX11, SOX17, DR1, and FOXH1 represses this module.

Key terms: regulation of mitotic spindle elongation regulation of spindle elongation protein localization to cytoskeleton anastral spindle assembly Notable genes: NUMA1 FANCM PCNT CEP43 MTBP IPO11 FIGN CEP350 Top TFs: SOX11 SMAD3 ARID1A SOX17 DR1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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