This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for NUMA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUMA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUMA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:71,786,388–71,787,283 | 293.4 kb | Distal (>10kb) Multiome | 289 | |
| chr11:71,928,161–71,929,328 | 151.7 kb | Distal (>10kb) Multiome | 869 | |
| chr11:72,040,697–72,041,585 | 39.5 kb | Distal (>10kb) Multiome | 586 | |
| chr11:72,080,144–72,081,188 | 149 bp | At TSS Multiome | 789 | |
| chr11:72,088,078–72,088,746 | 7.8 kb | Proximal (<10kb) Multiome | 50 | |
| chr11:72,089,150–72,089,648 | 8.6 kb | Proximal (<10kb) | 15 | |
| chr11:72,102,846–72,104,062 | 22.8 kb | Distal (>10kb) Multiome | 870 | |
| chr11:72,111,979–72,113,129 | 32.0 kb | Distal (>10kb) Multiome | 901 | |
| chr11:72,222,505–72,225,138 | 142.8 kb | Distal (>10kb) Multiome | 815 | |
| chr11:72,237,525–72,239,038 | 157.7 kb | Distal (>10kb) Multiome | 427 | |
| chr11:72,239,350–72,240,441 | 159.3 kb | Distal (>10kb) Multiome | 349 | |
| chr11:72,243,706–72,244,831 | 163.7 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the NUMA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.