Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Transcription factors with Perturb-seq knockdown data for IPO11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IPO11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IPO11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:62,138,351–62,139,212 | 274.0 kb | Distal (>10kb) Multiome | 146 | |
| chr5:62,218,824–62,219,304 | 193.7 kb | Distal (>10kb) Multiome | 27 | |
| chr5:62,305,482–62,307,335 | 106.6 kb | Distal (>10kb) Multiome | 1045 | |
| chr5:62,403,358–62,404,699 | 8.8 kb | Proximal (<10kb) Multiome | 1008 | |
| chr5:62,411,784–62,413,278 | 87 bp | At TSS Multiome | 867 | |
| chr5:63,958,654–63,960,090 | 1546.7 kb | Distal (>10kb) Multiome HiCAR | 324 |
Genomic view of the IPO11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.